Exchange Server 2007 and earlier versions:Coexistence with Exchange 2007 or earlier is not supported.
Exchange Server 2010:
Supported with Update Rollup 11 for Exchange 2010 SP3 or later on all Exchange 2010 servers in the organization, including Edge Transport servers.
Exchange Server 2013:
Supported with Exchange 2013 Cumulative Update 10 or later on all Exchange 2013 servers in the organization, including Edge Transport servers.
Mixed Exchange 2010 and Exchange 2013 organization:
- Supported with the following minimum versions of Exchange:Update Rollup 11 Exchange 2010 SP3 or later on all Exchange 2010 servers in the organization, including Edge Transport servers.
- Exchange 2013 Cumulative Update 10 or later on all Exchange 2013 servers in the organization, including Edge Transport servers.
Hybrid Deployment:
Exchange 2016 supports hybrid deployments with Office 365 tenants that have been upgraded to the latest version of Office 365.
Supported Clients:
Exchange 2016 and Exchange Online support the following versions of Outlook:
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Outlook 2016
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Outlook 2013
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Outlook 2010 with KB2965295
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Outlook for Mac for Office 365
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Outlook for Mac 2011